Background. Osteoarthritis (OA) is the most common form of arthritis and some joints are predisposed more than others. The prevalence of OA increases with age and it represents the major problem for functional impairment in older patients.
Purpose. This study was performed to determine efficiency of ozone + PRP (platelet rich plasma) injections on pain in patients with knee osteoarthritis.
Material and Methods. 102 patients with the diagnosis of OA according to the criteria of the American College of Rheumatology were enrolled in this study. Patients were randomized into three equal groups (34 patients each group).
Patients in the first group were treated with intra-articular injections of ozone 2 times/week, with 10 µg/ml ozone, 5 mL in volume for a total of 12 times .
Patients in the second group were treated with intra-articular injections of PRP + ozone (10 µg/mL ozone, 5 mL volume) once a week for a total of 3 times.
Patients in the third group were treated only with PRP injections once a week for a total of 3 times.
The pain levels of patients were measured with visual analog scale (VAS). We chose the patients with VAS score 5 and above.
The improvement strength has been evaluated according to Clinical Global image scale.
Keywords: Ozone knee injection; PRP knee injection; Osteoarthritis